Biochemist's Songbook



	*** Protein Synthesis *** (tune: My Bonnie Is Over The Ocean )

	The primary sequence of proteins
	Is coded within DNA
	On the sense strand of the double helix
	coiled antiparallel way

	(chorus:)
	Intron and exons
	changes are posttranscriptional, and all
	Glycosylations
	Don't alter such basics at all

	(... and so on for about 15 stanzas. The synthesis of proteins from DNA is a
	complex pathway....)



	*** The Michaelis Anthem *** (tune: The Red Flag)

	The substrate changed by an enzyme
	Initially, in unit time
	Varies, if not in excess
	With substrate concentration, [S]
	If enzyme concentration's low
	And reaction back from product's slow
	Then if we choose a steady state
	Velocity and [S] relate.

	This relationship can be derived
	As Briggs and Haldane first contrived:
	The unbound enzyme, [E], we guess
	Is [E0]	 (total), less [ES]
	k1[S][E] gives [ES] formation
	and k2[ES], dissociation
	And [ES] gives the product, P,
	At a rate that's [ES] times k3

	When [ES] is at the steady state
	These terms are all seen to relate
	([E0] less [ES]) times k1[S]
	Equals (k2 + k3) times [ES]
	Now the maximum velocity
	is k3[E0], (or big V)
	These terms can be manipulated
	If one more definition's stated

	Define as Km (just for fun)
	(k2 + k3) on k1
	And note that v (velocity)
	Is always [ES] times k3
	Then rearranging these equations
	We get the final rate equation
	V times [S] on Km + [S]
	is v (initial) - more or less
	

	*** The Respiratory Chain *** (tune: Battle Hymn of The Republic)

	My eyes have seen the glory of respiratory chain
	In every mitochondrium intrinsic to membranes
	Functionally organised in complex sub-domaines
	Where electron flow along

	(chorus)
	Glory, glory respiration
	Glory, glory respiration
	Glory, glory respiration
	Where electrons flow along








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